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Benefits of citrulline malate

Citrulline malate is a supplement that is used to boost the production of nitric oxide in the body, which helps provide blood flow and nutrients to the muscles. This supplement has been studied for its effectiveness in treating erectile dysfunction, exercise performance, and muscle fatigue.

In this article, we will find out the benefits of taking citrulline malate for bodybuilding and overall health.

Difference between L – citrulline and citrulline malate

L-citrulline is a precursor for arginine, which leads to the creation of nitric oxide in the body, thereby increasing blood flow. Citrulline Malate is a salt form of L-citrulline, which makes it easier for the body to absorb it.

Some studies found that citrulline malate may be more beneficial than L-citrulline because it is more stable in neutral pH environments. Citrulline Malate has also been shown to have greater solubility and bioavailability than L-Citrulline.

What are the benefits of citrulline malate?

1.Improved blood flow to the muscles

Citrulline is a precursor for another amino acid known as L-arginine. Arginine gets readily converted into nitric oxide. Nitric oxide is a molecule that is created naturally by the body to regulate blood pressure.

Nitric oxide is responsible for dilating the blood vessels thus improving blood flow which ultimately means getting proper nutrients and water to the muscle cells resulting in improved endurance and less recovery time in between sets.

Nitric oxide can be destroyed by cigarettes, air pollution, and as a result, our lungs cannot filter out toxins from the air. Nitric oxide has been implicated in lowering blood pressure, dilating airways, and improving sleep quality.

2. Reduces fatigue

During exercise, the muscles produce a compound called lactic acid. When this build-up occurs, lactic acid triggers a burning sensation known as the “peripheral muscle pain”.

When a person’s lactic acid levels become too high, their muscles will start to burn fuel to overcome this build-up and this means that the energy costs of a session can increase, leading to fatigue.

Studies show that citrulline malate plays an important role in breaking down lactic acid, which helps to decrease muscle fatigue thus improving overall exercise performance in the gym. Citrulline also helps to increase energy levels, increase endurance for workouts, and improve cardiovascular health.

3. Improves penile function for ED patients

In a research, it was concluded that men with mild erectile dysfunction (ED) benefit most from taking the supplement L- citrulline or citrulline malate. In particular, the study highlighted the following beneficial effects of CM:

The supplement is known to improve the blood flow and function of arteries. In turn, this improves blood flow to the penis, making it easier for an erection to be achieved.

Although it is not a replacement for ED medications such as viagra or cialis. As we saw above, citrulline works by increasing nitric oxide production which results in improved blood flow in the body.

4. Helps in lowering high blood pressure

Blood pressure is a highly regulated function that responds to changes in the amount of oxygen in the blood. In studies, oral doses of L-citrulline of up to 6mg a day have been found to decrease systolic blood pressure when compared to a placebo.

When citrulline malate is absorbed into the bloodstream, it enters the mitochondria of the muscle cells where it converts into L-citrulline, which then reaches the blood plasma.

When the blood plasma is stimulated by exercise, L-citrulline levels in the blood increase dramatically. L-citrulline’s role is to boost the cells’ ability to transport oxygen around the body.

This increased blood flow helps to decrease blood pressure and improves the flow of blood to the heart. In the process, this helps to bring blood back to the heart’s core where it can easily beat and push blood around the body.

5. Improves immune function

Citrulline has received attention for its potential benefits to immune function. For example, it may improve the natural production of glutathione which boosts the immune system’s ability to fight off infection.

Preliminary evidence suggests that citrulline malate may improve T-cell function, decrease markers of oxidative stress, and thereby improve immune function. However further research is need in this topic.


Citrulline is an amino acid and a conditionally essential nutrient. Citrulline is not considered essential because the body can produce it from lysine, ornithine, and methionine. It is therefore classified as a semi-essential or conditionally essential amino acid.

The increased level of citrulline in the blood reduces the ammonia level of urea cycle intermediates, increasing excretion of toxic ammonia by the kidneys.

Citrulline also increases nitric oxide levels in the blood vessels, which are associated with lower blood pressure and improved circulation.

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